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AMPK may be directly amenable to activation by semaglutide, and mitophagy may be initiated by AMPK phosphorylation of parkin [77,156,157]

In their seminal study, Peterson and Sullivan utilised a novel non-peptide glucagon receptor antagonist (Bay 27-9955) in healthy, lean males to investigate effects on glycaemia (51)

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Am J Clin Nutr 104(3):694703 [DOI] [PubMed] [Google Scholar] 47.Arnal MA, Mosoni L, Boirie Y, Houlier ML, Morin L, Verdier E et al (1999) Protein pulse feeding improves protein retention in elderly women

1 The hypersomnolence signal is best understood as mild excess daytime sleepiness, not the severe sleep-attack pattern of narcolepsy