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Results Development of the secreted Exe4 peptide-coding gene To develop a one-shot in vivo genome editing-based therapy for DIO and pre-diabetes, we targeted the liver due to its large size and ease of transduction, anticipating effective therapeutic peptide/protein production and secretion following successful genome editing (Fig

Animal studies and small human trials have shown similar trends, and this new study builds additional evidence with larger and more generalizable real-world populations

GLP-1R/GIPR dual agonists improve lipid metabolism, with greater potential than GLP-1RAs

Improvements in lipid levels also have been observed during treatment with GLP-1 receptor agonists

Despite a few potential ocular risks caused by GLP-1RAs, more clinical studies continue to discover and confirm their beneficial role in the eye, providing hope for creating a new weapon to treat eye diseases