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Gut 38:916919 Hansen L, Hartmann B, Mineo H, Holst JJ (2004) Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum

Your intestines are smooth muscle

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But because food is staying in your stomach and digestive system for an extended period of time and the impact on certain receptors in the brain, it raises your risk for the most common gastrointestinal GLP-1 side effects, like nausea, vomiting, diarrhea, and constipation

Semaglutide and tirzepatide are the two primary GLP-1 medications prescribed for weight management