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The FDA has approved tirzepatide (as Zepbound for weight management and Mounjaro for type 2 diabetes) at standard doses starting at 2.5 mg weekly

The time for age-specific approaches to young-onset MASLD is not in some distant future but now, as Generation MASLD enters adulthood ill-served by current clinical paradigms

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Reduced incretin hormone synthesis in response to meals (hyposecretion) and diminished insulinotropic action on pancreatic beta cells [14] are two explanations that have been put forward for the attenuation of the incretin effect in T2DM [15]

Lyophilized tirzepatide has an expiration date on the vial