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It is imperative to emphasize that these findings predominantly originate from animal studies and experiments conducted with cell lines
The addition of glucagon receptor agonism is particularly notable: preclinical evidence and early human data suggest it may increase energy expenditure and promote fat breakdown (lipolysis), potentially offering greater weight reduction than dual agonists alone though the precise contribution of each receptor in humans remains an active area of research
26 The patient discontinued her regimen of metformin and dapagliflozin 2 days prior to admission
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