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Much of this research involved short-term use, tested only one or a few doses, and included a small number of participants

At Set Point Medical Weight Loss Clinic, most patients begin noticing a reduction in appetite within the first few weeks, particularly as the dosage increases

Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]