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Regular monitoring of weight, kidney function, serum bicarbonate, and nutritional status is essential during combination therapy
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However, the ability of glucagon to bind to the GLP-1r is extraordinarily less potent than GLP-1 (221)
They approach what bariatric surgery produces, which is roughly 25 to 30% weight reduction, and they do so with a weekly subcutaneous injection rather than a surgical procedure
Dietary fiber, protein intake, and regular exercise do modestly increase endogenous GLP-1 secretion
December 30, 2023
