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-When changing treatment regimens, the dose and frequency of short-acting insulin may need to be adjusted

Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen: Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, or injection site or method of administration) may affect glycemic control and predispose to hypoglycemia or hyperglycemia

Reviews suggest that improvements in other conditions, like blood pressure and knee pain, are mostly linked to weight loss rather than a strong direct drug effect

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In the SURPASS-EARLY trial, nearly 800 adults diagnosed with type 2 diabetes within the past four years whose disease was not adequately controlled with metformin, diet and exercise were assigned to add either tirzepatide or other medications
