issues with glp 1 drugs GLP-1 Medications Infographic GLP-1 Safety Check - National

Tirzepatide and semaglutide performed similarly - so the impact on heart failure was not directly correlated to weight loss

10.1007/s00228-014-1727-5 76 GuptaV.KalraS

moreover it is still unclear whether GIP has direct, insulin independent, metabolic effects on adipose tissue

Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO (37)

Results showed that tirzepatide reduced the odds for all observed cardiometabolic abnormalities, including a 34% reduction in odds for decreased HDL-C, 72% reduction for MetS