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This is the point where FSH, LH, estradiol, and thyroid markers give you the data to make an informed decision about whether to continue escalating, hold your dose, or modify your caloric intake to reduce the metabolic stress signal to the hypothalamic-pituitary-ovarian axis
Duration of effect this is a key question that has not yet been studied in retrospective or prospective trials on addiction
Many insurance plans will not reimburse drugs for obesity, because they view weight loss as a lifestyle choice

The plotter makes this dramatically clear

A clinical trial showed that with Wegovy, the major adverse cardiovascular events (heart attack, stroke, cardiovascular death) can be reduced by 20% in specific patients with heart disease