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Nausea and vomiting appear to be most common when people overeat or potentially overeat fat which also slows down gastric emptying and could further worsen symptoms

**Percent Daily Values are based on a 2,000 calorie diet

IC025, the lower limit of 95%CI of the IC

Studies have suggested that the N-terminal residues His7, Gly10, Phe12, Thr13 and Asp15 are essential for interaction with the GLP-1 receptor, as substituting these residues with L-Ala leads to a severe loss of affinity for its receptor [43]

However, it is a very common secondary effect caused by dehydration from nausea, vomiting, or a decreased natural urge to drink water