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Despite producing more weight loss, tirzepatide had lower rates of treatment discontinuation due to gastrointestinal adverse events (2.7% vs 5.6% for semaglutide)

Ghrelin (the hunger hormone) increases with sleep deprivation, while leptin (the satiety hormone) decreases

A B-complex vitamin, adequate protein, electrolytes, and magnesium glycinate (for sleep quality) address the most common nutritional causes

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They are not presented as approved treatments for people