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For example, semaglutide 2.4mg (Wegovy) has demonstrated approximately 15% weight loss at 68 weeks in clinical trials, while liraglutide 3mg (Saxenda) typically achieves around 8% at 56 weeks

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However, a significant increase in Bifidobacterium, Dialister , and Alistipes was reported (73)

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Potential Side Effects and Long-Term Risks Common side effects include nausea, vomiting, digestive issues, and fatigue

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Heres a summary of non-injection options: Rybelsus This is the only widely available oral GLP-1 medication

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Most arent FDA-approved

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