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The company attributed the shortfall to increased operating expenses and lower patient volumes
A 2024 study comparing tirzepatide to semaglutide found that people taking tirzepatide lost significantly more weight than those taking semaglutide

Risk of hepatic events associated with use of sodium-glucose cotransporter-2 inhibitors versus glucagon-like peptide-1 receptor agonists, and thiazolidinediones among patients with metabolic dysfunction-associated steatotic liver disease

Dieting and weight cycling as risk factors for cardiometabolic diseases: who is really at risk

The trade-off between greater efficacy and increased side effect burden is real
