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A clinical review published in 2025 proposed that GLP-1 agonist modulation via increased serotonergic activity at the 5-HT2C receptor may result in diminished sexual desire
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The SURMOUNT trials showed continued improvement in depression scores through week 72
In situ hybridization studies in animal models demonstrated GLP-1 receptor presence in many other brain areas such as the thalamus, nucleus accumbens, and hindbrain
