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This is one way tirzepatide works for weight loss

GLP-1 helps in stimulating insulin production

The results revealed that low serotonin levels weakened communication between the amygdala (which processes emotions like anger) and the prefrontal cortex (which regulates emotional responses), impairing the brains ability to control irritability and anger, leading to heightened emotional reactions

In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

In SURMOUNT-1, participants treated with tirzepatide over 72 weeks experienced average weight reductions of up to 20.9% of their baseline body weight, depending on the dose used