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with one of the randomized, controlled trials contributing to its FDA approval demonstrating up to 8.2% weight loss

It is possible for Semaglutide GLP-1 to be prescribed off-label for weight management in cases where patients fall outside these criteria, depending on individual assessments by healthcare providers

Daniel Drucker, a professor at the University of Toronto Faculty of Medicine in Canada and a former adviser to Eli Lilly, said, "It shows the most powerful weight-loss effect among GLP-1 drugs developed so far" and evaluated it as "an effect on par with bariatric surgery (metabolic surgery for obesity)." He added, "If approved, most patients who need substantial weight reduction will choose retatrutide."

This means it works by stopping the bacteria from growing and reproducing

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