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Over time, these processes gradually become less efficient, leading to the accumulation of biological changes that affect metabolism, tissue function, and resilience across organ systems

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Measurable weight loss commonly starts within 4-6 weeks, with larger changes accumulating over 3-6 months

Most individuals start to notice a reduction in appetite and may begin to experience gradual weight loss within 2 to 4 weeks of starting the medication

See our July 2026 FDA action analysis and 503A vs 503B guide
