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NEWS IN BRIEF Lillys tirzepatide and Novo Nordisks semaglutide vie for top drug spot Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access 265,23 per year only 22,10 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Nature Reviews Drug Discovery 24 , 897 (2025) doi:

Some neurons predominantly responded through G_s-cAMP pathways, whereas others showed heightened sensitivity to G_q-mediated calcium signaling

Compounded semaglutide at $199 monthly might be better tolerated by some people who struggle with tirzepatide, though it can cause similar side effects

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