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2014, Yusta et al

Caloric restriction affects serotonin and dopamine production

In the 1980s, researchers at Massachusetts General Hospital discovered a hormone called GLP-1, a natural signalling molecule that tells your brain you're satisfied and should stop eating. This was interesting science, but nobody knew what to do with it

10.1038/jcbfm.2015.126 97

Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, and its approximately six-day half-life means plasma levels remain stable regardless of injection hour
