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These agents have been demonstrated to modulate appetite, taste preference, gut hormones, and regional body fat stores in adults with obesity without reduction in lean body mass

10.1124/jpet.103.051987 161

In South Africa, demand accelerated following the launch of Wegovy and Mounjaro, with some patients turning to compounded products because branded medicines were expensive or difficult to access

doi: 10.1210/endo-127-6-2779

Nausea is a very common side effect when starting AOM however a minority of patients are very sensitive to AOM and even the starting dose can result in them having severe nausea and difficulty eating anything or even drinking water, risking dehydration and kidney injury