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Biomarkers, Genetics, and Personalized GLP-1 Response Emerging evidence suggests that genetic variants in GLP-1 receptor, GIPR, FTO, and MC4R pathways may influence individual medication response and metabolic phenotype

Mechanism #2: Metabolic Adaptation & Adaptive Thermogenesis (The Survival Response) Whats happening: Your body interprets caloric restriction as a threat and actively slows your metabolism to conserve energy

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doi: 10.1016/S2213-8587(16)30005-5 10 MondinACeccatoFVoltanGMazzeoPManaraRDenaroLet al

Semaglutide works by mimicking the GLP-1 hormone, which tells your brain you are full and helps your body process blood sugar more effectively