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Methods This narrative review is based on a comprehensive analysis of the supplied literature set, prioritizing high-level evidence from systematic reviews, meta-analyses, clinical guidelines, and key original studies published between 2021 and 2025

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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.