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The mechanism that slows gastric emptying, believed to cause gastroparesis, is present in both semaglutide and tirzepatide drugs

Some people experience a brief weight plateau or small regain of 1-3 pounds during transition, which typically stabilizes within four to six weeks

For now, the available evidence supports sustained treatment as the expected clinical pattern, with dose-reduction strategies as a reasonable secondary option for patients who reach their target weight and want to explore the lower end of the maintenance range

doi: 10.1016/S0140-6736(18)32261-X 13 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

From a digestive standpoint, semaglutide: Slows stomach emptying Reduces appetite Increases feelings of fullness Slows intestinal motility These effects are part of why semaglutide can be effective for blood sugar control and weight loss