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GIP-agonism has no effect on cardiac ischemia, despite stimulating hormone-sensitive lipase phosphorylation and fatty acid oxidation, supporting the cardiac safety of GIP receptor agonism (RA) for use in multi-receptor agonism

There were several study limitations identified by the researchers

The most striking result in the paper may actually be the 44% reduction in all-cause mortality, Yi said

The multiple conformations observed from the single-particle EM analysis of the purified Fab7F38semaglutideGLP-1RGsNb35 complex most likely represent different agonist-bound ECD conformations, however some 2D classes are also compatible with the closed conformation observed in our inactive crystal structure (Supplementary Fig