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Weight regain was the primary outcome and was modelled using nonlinear regression

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This suggests we may be able to decouple cardiometabolic benefit from weight loss entirely

Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials