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Weight loss and lifestyle changes have proven to be effective in restoring menstrual regularity and reproductive function, improving hyperandrogenism, glucose and lipid metabolism, and insulin sensitivity, thus reducing cardiovascular risk in women with PCOS [18,19,20]

Trial data show an average increase of about 2.7 to 3.2 beats per minute in some studies, and real-world program data report a slightly higher proportion of people reporting increased heart rate on semaglutide versus not on it (for example, roughly 16 percent versus 11 percent after two years in an extensive registry analysis)

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Other STEP trials reported similar sustained losses around 15%

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