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The findings suggest that GLP-1RAs may have disease-modifying effects in knee OA, primarily mediated by weight reduction [145]

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However, the agencies analyses at the time were hindered by the small number of reported instances of suicidal thoughts and behaviors, resulting in what the FDA on Monday called considerable uncertainty in the risk estimate. For more clarity on the matter, the agency conducted a meta-analysis of different GLP-1 trials, encompassing more than 90 studies and nearly 108,000 patients

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In the 2026 Monitoring Program , the monitoring of semaglutide has been adjusted