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However, FXR activation decreases both proglucagon mRNA levels and GLP-1 secretion in response to glucose [175, 176]
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Avoid stimulant laxatives long-term without medical guidance
GIP receptor activation works synergistically with GLP-1 enhancing insulin release, improving adipose tissue metabolism, improving lipid handling, and critically, moderating the gastrointestinal side effects that limit tolerability of pure GLP-1 agonists
