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Importantly, while weight loss was observed in these trials, the degree of improvement in cardiac outcomes were often disproportionate to the weight reduction alone, suggesting at weight loss-independent mechanisms 30,31,44

Conversely, in SAVOR-TIMI 53 (saxagliptin assessment of vascular outcomes recorded in patients with DM thrombolysis in myocardial infarction) trail, Scirica et al

Ive seen some patients on the maximal dose have zero side effects and Ive seen other patients on a very minimal dose and have more severe side effects

These include decreased urination or dark-colored urine, dizziness or lightheadedness, extreme thirst and dry mouth, or unusual tiredness and weakness

I cannot wait to see the end result