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Pharmacologic therapies, including glucagon-like peptide-1 receptor agonists and thyroid hormone receptor- agonists, improve histologic endpoints and fibrosis regression, although heterogeneity among clinical trials precludes direct comparison

Among patients who discontinued, the cumulative incidence of treatment reinitiation was 41.1% at 1 year and 57.4% at 3 years after discontinuation

For appropriately selected adolescents, pharmacotherapy may provide an important additional tool to improve weight-related health outcomes and reduce long-term cardiometabolic risk

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Conclusions/interpretation These results suggest that CB1R could be an interesting target for type 1 diabetes while highlighting the regulatory mechanisms of insulitis