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Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(736) amide in rats

According to him 'this was contrary to everything that was then believed about the physiological role of glucagon in glucose homeostasis if indeed there was one.' Just a couple of years before, Yalow and Berson had detected larger than normal rises in the plasma insulin levels in insulinoma patients injected with glucagon, but concluded this was due to insulin released from the liver

This occurs through the phosphorylation of myosin light chain (MLC) by ROCK, resulting in cytoskeletal reorganization and changes in endothelial cell adhesion
