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When combined with tirzepatide neurochemical effects, the cumulative impact may exceed what either would produce alone

Common supportive supplements during tirzepatide therapy include B12 for energy support, B6 for nausea management, probiotics for gut health, magnesium for constipation and muscle function, and fiber supplements for digestive regularity

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In people without diabetes, Mounjaro still slows digestion and reduces appetite, so digestive side effects remain the most common

For weight management, Zepbound is indicated for adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbid condition