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Randomized controlled trials will eventually answer the questions that pilot studies and mechanistic evidence can only suggest

In addition, GLP-1RAs can effectively upregulate the expression of myogenic regulatory factors MyoD and MyoG, while inhibiting the transcription of key ubiquitin-ligases MAFbx and MuRF1 in muscle atrophy

You also want to maintain an active lifestyle and do at least 30 minutes of weight training 5 days a week

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More serious but rare concerns include pancreatitis, gallbladder problems, and potential thyroid tumor risk (observed in rodent studies but not confirmed in humans)