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Metabolic Rate Considerations Men naturally have higher resting metabolic rates than women, which means absolute calorie expenditure during treatment is higher

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Mercado-Valenzo and Ms Jiaxu Li for their feedback during the preparation of the manuscript

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Clinical evidence shows slow titration produces the same final weight loss as rapid dose escalation but with fewer dropouts due to side effects

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Metabolic adaptation is most likely the reason for this plateau [11] rather than poor response or resistance to the medication

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