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Liver-expressed antimicrobial peptide 2 (LEAP2) was first isolated in 2003 from human blood and characterized as a cationic antimicrobial peptide with protective functions against bacterial infection [22]

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Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 19802017: a systematic analysis for the global burden of disease study 2017

The reason: If you already have thinning bones (osteopenia or osteoporosis) or severe loss of muscle mass, losing weight can exacerbate those problems especially if you fail to build adequate aerobic and strength-training exercise into your regimen