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In the clinic, we often aim for gradual weight loss with adequate protein and micronutrient intake

Risk factors for greater lean tissue loss likely include advanced age, rapid or large absolute weight loss, low dietary protein intake, sedentary lifestyle, and comorbid conditions such as chronic kidney disease or long-standing diabetes [15]

Lowering Systemic Silent Inflammation As highlighted in advanced blood panels, chronic, lowgrade inflammation (measured by hsCRP) is the primary driver of cardiovascular disease and biological aging

Risk increases with rapid or significant weight loss

The pancreas typically produces adequate digestive enzymes in patients without pancreatic insufficiency, and GLP-1 receptor agonists do not directly inhibit enzyme synthesis