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The safety profile at weekly dosing is well-established and favorable for most patients

Preclinical studies have demonstrated that GLP-1 receptor activation enhances neurogenesis and neuronal survival, reduces oxidative stress, improves insulin sensitivity in the brain and inhibits neuroinflammationkey factors implicated in neurodegeneration

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Furthermore, performing subgroup analyses based on background glucose-lowering therapy was not feasible due to the varied treatments across trials