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Under normal physiological conditions, several mechanisms restrict LPS signaling within the gut lumen

The medication's appetite-suppressing effect is powerful enough to create a calorie deficit passively

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Abbreviations AACE: American Association of Clinical Endocrinology AE: Adverse event CDS: Chinese Diabetes Society DPP-4i: Dipeptidyl peptidase-4 inhibitor ETD: Estimated treatment difference FPG: Fasting plasma glucose GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist PIONEER: Peptide Innovation for Early Diabetes Treatment SAE: Serious adverse event SF-36v2: 36-item Short Form Health Survey (Acute Version) SMPG: Self-monitored plasma glucose References Sun H, Saeedi P, Karuranga S et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Oral tablets must be taken on an empty stomach 30 minutes before food, and peak blood levels appear within one to three hoursa faster but shorter-lived effect that some patients find easier to tolerate