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The interaction with phenytoin is particularly noteworthy, as sertraline can increase phenytoin levels, potentially leading to toxicity

CDC data show rising GLP-1 use as part of diabetes therapy, reflecting guideline adoption

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18 The SYNERGY-NASH (A Study of Tirzepatide [LY3298176] in Participants With Nonalcoholic Steatohepatitis) trial, 19 a phase 2b dose-finding study, randomized 190 patients with biopsy-confirmed MASH and stage 2 or 3 fibrosis to receive weekly injections of the GLP-1 and GIP dual agonist tirzepatide 5 mg, 10 mg, or 15 mg or placebo for 52 weeks

However, Glp1r/ mice treated with the GLP-1/Gcg coagonist experienced a reduction in body weight and fat mass but did not have improvements in glucose tolerance indicating that GLP-1R agonism is required to counteract the hyperglycemic effects of GcgR agonism (Day et al., 2009)