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GLP-1 medications were originally designed as medical tools for diabetes management, not quick fixes for poor metabolic habits

While these symptoms are nonspecific, they may indicate hypomagnesemia, especially in patients with chronic diarrhea, malabsorption, or poorly controlled diabetes

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Other residues, although accessible, were either clustered near symmetry axes ( e.g ., D12, F96, K142), exhibited lower surface exposure ( e.g ., D12, E88), or were located in more flexible sections ( e.g ., E81 in the long loop), making them less suitable for conjugation

Some studies suggest that GLP-1-RAs, including semaglutide, may improve the sensitivity of cells to insulin