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The retrospective data should encourage prospective trials in this space, Arman Qamar says.

The GLP-1R agonist liraglutide alleviated basal allodynia and suppressed the upregulation of CGRP, c-fos and PI3K/p-Akt in the TNC

Dual-agonists such as GLP-1R/GIPR (e.g., Hengruis HRS9531) and triple-agonists such as GLP-1R/GIPR/GCGR (e.g., United Laboratories UBT251) represent the next technological wave, aiming for superior weight loss and broader metabolic benefits

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