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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Mehrtash F, Dushay J, Manson JE

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

If your period has stopped, consult a medical provider to rule out pregnancy and other medical conditions

Publication bias and sensitivity analysis Funnel plots were constructed to assess potential publication bias for the outcomes of AF, acute myocardial infarction, and nephrolithiasis

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