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Intriguingly, a first-of-its-kind SGLT2i trial and secondary analysis in patients with HFmrEF and HFpEF showed a 29% reduction in patients' risk of HHF [74, 75], although this effect was diminished in patients with EF 65%

Nathan DM, Lachin JM, Bebu I, Burch HB, Buse JB, Cherrington AL, et al

What are the benefits of Semaglutide GLP-1 injection

Additionally, loss of muscle mass during rapid weight loss can reduce the efficiency of muscle pumps that help return blood from the extremities to the heart, leading to blood stasis, particularly in the legs, which is a risk factor for deep vein thrombosis (DVT)

Other GLP-1 drugs also affect oral contraceptives to varying degrees