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Plasma DPP-4 activity and TG excursion were reduced, and plasma active GLP-1 was increased, in sitagliptin-treated Dpp4 +/+ mice, but sitagliptin had no effect in Dpp4 / mice (Figure 1, B and C, and Supplemental Figure 3, A and B), consistent with the selectivity of sitagliptin for DPP-4 (22)

When immune regulation becomes impaired, the body's ability to eliminate infections may be compromised

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Drug incorporation techniques Once the microneedles are fabricated, drug incorporation is a critical step to ensure that the active pharmaceutical ingredient (API) is effectively delivered to the target area in the skin [57]