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A 2025 review in Medicina further examined how incretin-based therapy affects skeletal muscle health, highlighting that GLP-1 medications can affect muscle mass (PMID: 41011082)

Essential supply checklist Your supply list depends on whether you are using a pre-filled pen or drawing from a vial

Common side effects include: Nausea Diarrhea Constipation Headache Fatigue Most side effects are temporary and manageable, especially with proper dosage adjustment and guidance from a knowledgeable pharmacist or prescriber

Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2) : Avoid use if you have this syndrome, which is associated with an increased risk of thyroid tumors

Novo Nordisk, which holds the patent on semaglutide, does not supply the ingredient to outside groups, NBC News noted