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Peripheral mechanisms appear to account for many of tirzepatide's metabolic effects

However, in older adults with co-morbidities or those with sarcopenic obesity, even modest reductions in lean mass can exacerbate functional decline [24]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Li Y, Tweedie D, Mattson MP, Holloway HW, Greig NH