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When fibre is fermented by gut bacteria, it produces short-chain fatty acids, which have been shown to stimulate GLP-1 secretion in the gut

Patient safety, treatment efficacy, and practice viability all depend on a provider's ability to navigate the nuances of patient selection, dose titration, side effect management, combination therapy, and long-term monitoring

FoxO1 is involved in the hepatic production of glucose and VLDL in the absence of insulin, as increased hepatic insulin signaling has been shown to inhibit FoxO1 and thereby reduce the release of glucose and VLDL from the liver by restraining microsomal triglyceride transfer protein ( MTP ) and apolipoprotein B ( ApoB ) expression [48,49,50]