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NOTE: Always correlate microscopy findings with clinical symptoms like persistent diarrhoea, recent antibiotic use, or diaper rash before labelling it clinically significant

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indeed, if some studies showed that the hormone is able to significantly downregulate autophagy in different disease models 63,64,65 , other reports failed to confirm those findings, providing evidence for an enhancement of the autophagic process upon melatonin treatment 66,67,68