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These claims are anecdotal and may not be substantiated with clinical evidence

puf-8(/) mutants were also suppressed by mpk-1(RNAi) (Supplementary Figure S5)
Though causative genes have been identified, the mechanisms through which the genetic mutations induce obesity are not completely understood in all cases[138]

Abstract Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis

Neurogenesis is defective in the AD model, which is characterized by decreased proliferation and differentiation, diminished neuronal maturity, and reduced survival, before processes that may secondarily affect neurogenesis, such as neuronal loss, amyloid deposition, and inflammation
